The structural network of Interleukin-10 and its implications in inflammation and cancer

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Acuner-Ozbabacan E. S. , Engin B. H. , Guven-Maiorov E., Kuzu G., Muratcioglu S., Baspinar A., ...More

BMC GENOMICS, vol.15, 2014 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15
  • Publication Date: 2014
  • Doi Number: 10.1186/1471-2164-15-s4-s2
  • Journal Name: BMC GENOMICS
  • Journal Indexes: Science Citation Index Expanded, Scopus

Abstract

Background: Inflammation has significant roles in all phases of tumor development, including initiation, progression and metastasis. Interleukin-10 (IL-10) is a well-known immuno-modulatory cytokine with an anti-inflammatory activity. Lack of IL-10 allows induction of pro-inflammatory cytokines and hinders anti-tumor immunity, thereby favoring tumor growth. The IL-10 network is among the most important paths linking cancer and inflammation. The simple node-and-edge network representation is useful, but limited, hampering the understanding of the mechanistic details of signaling pathways. Structural networks complete the missing parts, and provide details. The IL-10 structural network may shed light on the mechanisms through which disease-related mutations work and the pathogenesis of malignancies.