Correlation Between Primary Tumour And Axillary Lymph Node ResponseTo Neoadjuvant Chemotherapy İn Breast Cancer Patients


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Kır G. , Olgun Z. Ç. , Okten I., Ankaralı H. , Girgin R. B. , Melemez M., et al.

31th European Congress of Pathology, Nice, Fransa, 7 - 11 Eylül 2019, cilt.31, ss.4-15

  • Cilt numarası: 31
  • Basıldığı Şehir: Nice
  • Basıldığı Ülke: Fransa
  • Sayfa Sayısı: ss.4-15

Özet

Background & Objectives: There can be inconsistencies between primary

tumour and axillary lymph node response to neoadjuvant chemotherapy

(NAC) in breast cancer patients. The aim of this study is to

evaluate this correlation.

Methods: A retrospective study was carried out in 114 nodepositive

breast cancer patients, who had axillary dissection, from

2 centers between 2009-2019 who treated with NAC before surgery.

Tumour response was evaluated pathologically as complete

response(CR)/partial response(PR)/without response(WR) by using

Sataloff et. all, 1995 for primary tumour and axilla seperately.

Results: Seventy-eight patients (69%) had statistically significant

consistency between NAC responses of primary tumour and

axilla(p:0,0001, kappa coefficent: 0.509). We had one patient with

major inconsistency between NAC responses (CR at primary tumour

and WR at axilla). After 19 months follow up she was devoid

of disease. Multivariate cox regression analysis revealed that

CR and PR were independent predictors of disease free

survival(DFS). (Primary tumour CR - CI:0.007-0.402, p:0.005;

Primary tumour PR – CI:0.059-0.352, p: 0.000; Axilla CR -

CI:0.012-0.654 p:0.018; Axilla PR - CI:0.073-0.529 p:0.001).

There were no significant differences between CR and PR for both

primary tumour and axilla regarding DFS (CI:0.342-21.893,

p:0.343; CI:0.263-19.315, p:0.458 respectively). Due to small

number of mortality we couldn’t reach statistical significance for

overall survival.

Conclusion: We observed significant correlation between NAC responses

of primary tumour and axilla. Both CR and PR of primary

tumour and axilla were independent predictors of DFS.