31th European Congress of Pathology, Nice, Fransa, 7 - 11 Eylül 2019, cilt.31, ss.4-15
Background & Objectives: There can be inconsistencies between primary
tumour and axillary lymph node response to neoadjuvant chemotherapy
(NAC) in breast cancer patients. The aim of this study is to
evaluate this correlation.
Methods: A retrospective study was carried out in 114 nodepositive
breast cancer patients, who had axillary dissection, from
2 centers between 2009-2019 who treated with NAC before surgery.
Tumour response was evaluated pathologically as complete
response(CR)/partial response(PR)/without response(WR) by using
Sataloff et. all, 1995 for primary tumour and axilla seperately.
Results: Seventy-eight patients (69%) had statistically significant
consistency between NAC responses of primary tumour and
axilla(p:0,0001, kappa coefficent: 0.509). We had one patient with
major inconsistency between NAC responses (CR at primary tumour
and WR at axilla). After 19 months follow up she was devoid
of disease. Multivariate cox regression analysis revealed that
CR and PR were independent predictors of disease free
survival(DFS). (Primary tumour CR - CI:0.007-0.402, p:0.005;
Primary tumour PR – CI:0.059-0.352, p: 0.000; Axilla CR -
CI:0.012-0.654 p:0.018; Axilla PR - CI:0.073-0.529 p:0.001).
There were no significant differences between CR and PR for both
primary tumour and axilla regarding DFS (CI:0.342-21.893,
p:0.343; CI:0.263-19.315, p:0.458 respectively). Due to small
number of mortality we couldn’t reach statistical significance for
Conclusion: We observed significant correlation between NAC responses
of primary tumour and axilla. Both CR and PR of primary
tumour and axilla were independent predictors of DFS.