A hormone-dependent feedback-loop controls androgen receptor levels by limiting MID1, a novel translation enhancer and promoter of oncogenic signaling


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KOEHLER A., Demir U. , KICKSTEIN E., KRAUSS S., AIGNER J., ARANDA-ORGILLES B., et al.

MOLECULAR CANCER, cilt.13, 2014 (SCI İndekslerine Giren Dergi)

Özet

Background: High androgen receptor (AR) level in primary tumour predicts increased prostate cancer (PCa)-specific mortality. Furthermore, activations of the AR, PI3K, mTOR, NF kappa B and Hedgehog (Hh) signaling pathways are involved in the fatal development of castration-resistant prostate cancer during androgen ablation therapy. MID1, a negative regulator of the tumor-suppressor PP2A, is known to promote PI3K, mTOR, NF kappa B and Hh signaling. Here we investigate the interaction of MID1 and AR.