Urinary kidney injury molecule-1 levels as a marker of early kidney injury in hypertensive patients

KADIOGLU T., UZUNLULU M., YIGIT KAYA S., OĞUZ A., GONENLI G., ISBILEN B., ...More

MINERVA UROLOGICA E NEFROLOGICA, vol.68, no.5, pp.456-461, 2016 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 68 Issue: 5
  • Publication Date: 2016
  • Journal Name: MINERVA UROLOGICA E NEFROLOGICA
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.456-461
  • Keywords: Hypertension, Hypertensive nephropathy, Biomarkers., STAGE RENAL-FAILURE, LIPOCALIN NGAL, DISEASE, BIOMARKERS, EXCRETION, KIM-1

Abstract

BACKGROUND: Kidney injury molecule -1 (KIM -1) is a type 1 tubular cell transmembrane protein that is found in high levels in early stages of acute kidney injury and is stated to have predictive value in the early diagnosis of chronic kidney diseases. In this study, the hypothesis was that higher levels of KIM -1 would be detected in hypertensive patients for the early detection of nephropathy. With this goal, urinary KIM -1 levels of hypertensive cases were compared with those of healthy controls, and associations of KIM -1 levels with microalbuminuria and glomerular filtration rate (GFR) were investigated.