The Algorithms Cruz Rodriguez (CR) are Proposing A Novel Vaccine RNAPeptide against Breast, Ovarian, and Lung Cancers Disease: Exosomes as Carrier in Cancer Progression and Metastasis

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Cruz-Rodriguez L., Dilsiz N. , Barea R.

Journal of Medical-Clinical Research Review, cilt.5, sa.2, ss.1-16, 2021 (ESCI İndekslerine Giren Dergi)

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 5 Konu: 2
  • Basım Tarihi: 2021
  • Dergi Adı: Journal of Medical-Clinical Research Review
  • Sayfa Sayıları: ss.1-16


We highlight the composition and function of exosomes produced during cancer disease

in our work, how these vesicles could function as carriers of the RNA-peptide molecule. Finally, according to

the algorithms CRUZ RODRIGUEZ (CR) we are proposing various methods to develop a novel vaccine against

breast, ovarian, and lung cancers. Therefore, six RNA-peptides from our previous study were chosen based on

the potential of inducing strong fusion stability (FS=58.50 cruz) and exosome affinity (EA=59.80 ro), Biological

Action (BA= 1.0223 ro/cruz). This result may lead to the development of promising new therapeutic approaches

in cancer management by using exosome-mediated miRNA-peptide vaccine therapy. Due to, according to the

algorithm CR the Optimal Biological Action (OBA) value for antitumoral RNA-peptide with Exosome as carrier

are: 0.8 < OBA < 1.3. These results suggest that the designed vaccine can elicit specific immune responses against

three types of cancer; however, these results need experimental studies to confirm the efficacy and safety profile of

the proposed vaccine structure.