WAPM Working Group on Nutrition Potential chronobiotic role of human milk in sleep regulation

Arslanoglu S., BERTINO E., NICOCIA M., MORO G. E.

JOURNAL OF PERINATAL MEDICINE, vol.40, no.1, pp.1-8, 2012 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Review
  • Volume: 40 Issue: 1
  • Publication Date: 2012
  • Doi Number: 10.1515/jpm.2011.134
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1-8
  • Keywords: Chronobiotic, chrononutrition, circadian, human milk, infant sleep, sleep, CIRCADIAN-RHYTHM, MELATONIN THERAPY, WAKE CYCLE, PREOPTIC AREA, BREAST-MILK, CGMP LEVELS, 1ST YEAR, INFANTS, TRYPTOPHAN, DISORDERS


Background: Organization of the sleep states and a normal sleep pattern in the neonatal period and early infancy is essential for brain development and plasticity. The establishment of a consolidated circadian sleep-wake cycle occurs between 1 and 4 months of life in term infants. This period may be even longer for preterm infants who are exposed to relentless interventions in neonatal intensive care units. The sleep should be respected and protected.