Objective: Group A Streptococci (GAS) is the most important bacterial cause of pharyngitis because antibiotic therapy can be prescribed and failure to treat it is associated with suppurative and nonsuppurative complications. Nonsuppurative complications occur after a latency period of a few weeks and include acute rheumatic fever, scarlet fever, streptococcal toxic shock syndrome, acute glomerulonephritis, and pediatric autoimmune neuropsychiatric disorder associated with group A streptococci. The aim of this study is to investigate the frequency of nonsuppurative complications in properly treated children with GAS pharyngitis.
Methods: We investigated the frequency of nonsuppurative complications in 1030 proven GAS pharyngitis patients between 5 and 15 years old who were properly treated by a prospective observational study. All patients diagnosed with GAS pharyngitis were followed prospectively using a standard form for six months by monthly phone calls.
Results: All the isolates recovered from the patients were susceptible to penicillin. Twentyseven (2.6%) patients developed scarlet fever and none of the other nonsuppurative complications developed in our patient cohort.