This paper aims to examine the role of economic policy uncertainty (EPU) on tourism investments across the samples of OECD, non-OECD, high-income, upper-middle-income, and low-income economies. We account for cross-sectional dependence and endogeneity and also incorporate economic development, financial development, and trade openness indicators in the analyses. By using annual data between 1996 and 2016 and a total of 101 countries, we provide robust estimates on the determinants of tourism investments. The findings from the Common Correlated Effects Mean Group (CCEMG) and the Group Mean approaches show that the EPU has a significant negative impact on tourism investments across the panels. Moreover, other estimates suggest that economic development, financial development, and trade positively contribute to tourism investments.