This study aims to investigate the effects of two different interventions on the self-efficacy and care burden in caregiver family members of patients with schizophrenia. This semi-experimental study involved those caring for family members with schizophrenia. The family members were divided into two experimental groups and one control group. Interpersonal psychotherapy techniques and psychoeducation interventions were together applied to the first group, the second group received only the psychoeducation. Interpersonal psychotherapy techniques applied together with psychoeducation were found to be more effective in reducing the burden of care and increasing the self-efficacy.