International Participation in Turkish Cardiology Congress, Antalya, Türkiye, 3 - 06 Ekim 2019, no.142
BACKGROUND AND AIM:Vasovagal syncope(VVS) is the most common cause of syncope which has multiple patho-physiological mechanism. Apelin is a newly defined adipokine, a member of the adipose tissue family and is an endogenous ligand for the G-protein coupled (APJ) receptor. In this study, we aimed to investigate the changes in Apelin level before and after the head up tilt (HUT) test in patients diagnosed with VVS.
METHODS:50 patients with VVS and 26 age and gender matched healthy volunteers were analysed. Pa-tients with VVS were classified as vasodepressor type, cardioinhibitory type or the mixed type according to HUT results. Blood samples were taken before and immediately after the test to evaluate Apelin level in both groups.
RESULTS:There were no difference between groups with regard to age (24.7±3.86 vs 25.92±3.33, p: 0.175), gender(66% female in VVS group vs %53 in control group, p:0.301). There was no difference between Apelin values in VVS and control group before the tilt table test (Apelin 225(114-412) vs 215(93-374), p 0.558 ). There was no statistically significant difference in both Apelin values, when the measured values were compared prior to and following the tilt test in the control group (Apelin 215(93-374) vs 198(93-374); p0.805). After Tilt table test, in patients with VVS, Apelin values were higher than baseline (Apelin 225(114-412) vs 1529(1152-2768); p<0.001).
CONCLUSIONS:In our study, Apelin levels significantly elevated after the tilt table test in patients with VVS. Further studies are needed to verify diagnostic and prognostic value of Apelin in patients with VVS.
Keywords: Vasovagal syncope, Apelin, Tilt table test