Stimulation of 5-Hydroxytriptamine 7 Receptor by LP-211 Boosts Angiogenic Response


Yesildal F., Doganci S., Yildirim V., Ozgurtas T.

INTERNATIONAL JOURNAL OF PHARMACOLOGY, cilt.16, ss.98-103, 2020 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 16 Konu: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.3923/ijp.2020.98.103
  • Dergi Adı: INTERNATIONAL JOURNAL OF PHARMACOLOGY
  • Sayfa Sayıları: ss.98-103

Özet

Background and Objective: The 5-hydroxytriptamine type 7 receptors (5-HT7Rs) belong to the serotonin receptor family and modulate many processes in organism and are also found in membrane of endothelial cells (ECs). The LP-211 is a selective agonist of 5-HT7Rs. The purpose of this study was to investigate the effects of activated 5-HT7Rs by LP-211 on regulation of angiogenesis. Materials and Methods: The effect of LP-211 was tested in vitro by cell proliferation and matrigel assays and in vivo by chick chorioallantoic membrane (CAM) assay. Results: Cell proliferation assay showed that LP-211 had a positive effect on EC proliferation. The LP-211 activated migration of ECs and promoted angiogenesis in matrigel assay in vitro. Stimulation of 5-HT7R by LP-211 caused a significant increase in angiogenic response compared to the control group in CAM assay in viva. The LP-211, selective agonist of 5-HT7R, was found to have an angiogenic effect in vitro and in viva. Conclusion: The 5-HT7Rs can be considered to have an important role in EC functions and angiogenesis. Thus, 5-HT7Rs may be a potential target for the therapeutic interventions aimed to regulate the process of angiogenesis in diseases such as varicose veins, peripheral vascular diseases or vasculature of solid tumors. The LP-211 may be a candidate to improve the ineffective circulation in related disorders.