Reduced cerebrospinal fluid levels of interleukin-10 in children with febrile seizures


ŞAHİN S., Uysal S., YENTÜR S. P. , Kacar A.

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, vol.65, pp.94-97, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 65
  • Publication Date: 2019
  • Doi Number: 10.1016/j.seizure.2019.01.008
  • Title of Journal : SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
  • Page Numbers: pp.94-97
  • Keywords: Cerebrospinal fluid, Cytokines, Febrile seizure, Interferon-beta, Interleukin-10, Interleukin-12, ANTIINFLAMMATORY CYTOKINES, IMMUNE-RESPONSE, ENCEPHALOPATHY, ACTIVATION, IL-1-BETA, BLOOD, CELLS, SERUM, IGG

Abstract

Purpose: The exact etiology of febrile seizures (FS) is still unclear. However, it is thought that cytokine network activation may have a causative role. Therefore, this study aimed to evaluate the levels of interleukin-12 (IL-12) as a proinflammatory cytokine, interleukin-10 (IL-10) as an anti-inflammatory cytokine, and interferon-beta (IFN-beta), a marker of toll-like receptor-3 activation as a host response to viruses. These cytokine levels were analyzed in the cerebrospinal fluid (CSF) of children after a FS.