Inflammatory myofibroblastic tumor of the breast: A case report

Karaoglu A. S. , Demir M. H. , Ayaz A., Uysal H., Soylemez T., Eren T. T. , ...Daha Fazla

International Journal of Human and Health Sciences, cilt.4, sa.4, ss.305-308, 2020 (Diğer Kurumların Hakemli Dergileri)

  • Yayın Türü: Makale / Vaka Takdimi
  • Cilt numarası: 4 Konu: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.31344/ijhhs.v4i4.218
  • Dergi Adı: International Journal of Human and Health Sciences
  • Sayfa Sayıları: ss.305-308


Inflammatory myofibroblastic tumors (IMTs) of the breast are extremely uncommon

lesions, usually labelled as a subgroup of inflammatory pseudotumors. They are composed

of inflammatory cells and bland spindle cells without nuclear atypia. Nearly half of all

IMTs of the breast include clonal translocation of the anaplastic lymphoma kinase (ALK)

gene, located at the chromosome band 2p23, and generally present with a palpable lump,

swelling, and pain. Herein, we present a 66-year-old female patient with pain, swelling and a

palpable lump in her right breast. A 40×26 mm sized T1A hypointense and T2A hyperintense

mass with slightly lobulated margins was detected at breast magnetic resonance imaging.

A mass associated with an intramammary lymph node was evaluated in the upper inner

quadrant of the right breast via mammography. The results were considered as BI-RADS

3. Breast-conserving surgery with sentinel lymph node biopsy was performed. During

pathological evaluation, cytoplasm with poorly-defined margins, and large-nucleoli tumor

cells with benign ducts between these tumor cells, were observed. Intensive inflammatory

cell infiltration and sclerotic changes in different areas were also noted. The lesion stained

positive for caldesmon, smooth muscle actin, vimentin, CD10, and S100; however, it was

negative for ALK on immunohistochemistry. The patient remained disease-free after the

surgical procedure.