Effects of L-NAME and timolol on aqueous IL-1 beta, IL-6 IL-8, TNF-alpha and NO levels after Nd : YAG laser iridotomy in rabbits


ER H., DOGANAY S., EVEREKLIOGLU C., Cekmen M. B. , DAGLIOGLU M., ISCI N.

EUROPEAN JOURNAL OF OPHTHALMOLOGY, vol.12, no.4, pp.281-286, 2002 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 4
  • Publication Date: 2002
  • Title of Journal : EUROPEAN JOURNAL OF OPHTHALMOLOGY
  • Page Numbers: pp.281-286

Abstract

PURPOSE. Pro-inflammatory cytokines are produced by tissues and play a vital role in the host inflammatory response and uveitis. Nitric oxide (NO) can be produced in large amounts as a response to experimentally-induced uveitis or cytokines. In this study, we measured the levels of pro-inflammatory cytokines such as interleukin (IL)-1beta, IL-6, IL-8, tumor necrosis factor (TNF)-alpha and free-radical in aqueous humor after Nd:YAG laser iridotomy in rabbits, and investigated whether timolol maleate an anti-glaucoma drug, or a NO synthase inhibitor, NG-nitro-L-arginine methyl esther (L-NAME) had an inhibitory effect on these molecules, since L-NAME is a known anti-inflammatory agent in rabbits.