Caffeic acid phenethyl ester exerts a neuroprotective effect on CNS against pentylenetetrazol-induced seizures in mice


İlhan A., Iraz M., Gürel A., Armutçu F., Akyol Ö.

NEUROCHEMICAL RESEARCH, cilt.29, ss.2287-2292, 2004 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 29 Konu: 12
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1007/s11064-004-7038-y
  • Dergi Adı: NEUROCHEMICAL RESEARCH
  • Sayfa Sayısı: ss.2287-2292

Özet

Since overexcitation of excitatory amino acid is an important mechanism in seizure genesis wherein free radicals have recently been suggested to play a critical role, we explored the effects of caffeic acid phenethyl ester (CAPE) administration in pentylenetetrazole (PTZ)-induced seizure in mice. CAPE prevents the oxidative damage in brain tissue induced by PTZ, scavenging reactive oxygen species (ROS). Our results demonstrate that CAPE treatment which prevents free radical production and ameliorates seizure severity may be useful at least as an adjunctive treatment of seizure disorders.

Since overexcitation of excitatory amino acid is an important mechanism in seizure genesis wherein free radicals have recently been suggested to play a critical role, we explored the effects of caffeic acid phenethyl ester (CAPE) administration in pentylenetetrazole (PTZ)-induced seizure in mice. CAPE prevents the oxidative damage in brain tissue induced by PTZ, scavenging reactive oxygen species (ROS). Our results demonstrate that CAPE treatment which prevents free radical production and ameliorates seizure severity may be useful at least as an adjunctive treatment of seizure disorders.