Glutathione S-transferase gene polymorphisms in presbycusis


Aras-Ates N., Unal M., Tamer L., Derici E., Karakas S., Ercan T., et al.

OTOLOGY & NEUROTOLOGY, cilt.26, ss.392-397, 2005 (SCI İndekslerine Giren Dergi)

Özet

Hypothesis: Glutathione and glutathione-related antioxidant enzymes are involved in the metabolism and detoxification of cytotoxic and carcinogenic compounds as well as reactive oxygen species. Reactive oxygen species generation occurs in prolonged relative hypoperfusion conditions such as in aging. The etiology of presbycusis is much less certain: however, a complex genetic cause is most likely. The effect of aging shows a wide interindividual range; we aimed to investigate whether profiles of (glutathione S-transferase (GST) M1, T1 and P1 genotypes may be associated with the risk of age-related hearing loss.