Relationship between circulating IGF-1 levels and traumatic brain injury-induced hippocampal damage and cognitive dysfunction in immature rats

Ozdemir D., Baykara B., Aksu I., Kiray M., Sisman A. R. , Cetin F. , ...More

NEUROSCIENCE LETTERS, vol.507, no.1, pp.84-89, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 507 Issue: 1
  • Publication Date: 2012
  • Doi Number: 10.1016/j.neulet.2011.11.059
  • Title of Journal : NEUROSCIENCE LETTERS
  • Page Numbers: pp.84-89


It is well known that traumatic brain injury (TBI) induces the cognitive dysfunction resulting from hippocampal damage. In the present study, we aimed to assess whether the circulating IGF-I levels are associated with cognition and hippocampal damage in 7-day-old rat pups subjected to contusion injury. Hippocampal damage was examined by cresyl violet staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. Spatial memory performance was assessed in the Morris water maze. Serum IGF-1 levels decreased in both early and late period of TBI. Decreased levels of serum IGF-1 were correlated with hippocampal neuron loss and spatial memory deficits. Circulating IGF-1 levels may be predictive of cognitive dysfunction resulted from hippocampal damage following traumatic injury in developing brain. Therapy strategies that increase circulating IGF-1 may be highly promising for preventing the unfavorable outcomes of traumatic damage in young children. (C) 2011 Elsevier Ireland Ltd. All rights reserved.