Vascular risk in women with a history of severe preeclampsia


Goynumer G., Yucel N., Adali E., Tan T., Baskent E., Karadag C.

JOURNAL OF CLINICAL ULTRASOUND, vol.41, no.3, pp.145-150, 2013 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.1002/jcu.21962
  • Journal Name: JOURNAL OF CLINICAL ULTRASOUND
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.145-150

Abstract

Background. To assess markers of vascular dysfunction and risk in postpartum women with a history of severe preeclampsia. Methods. Carotid intima-media thickness (CIMT) and brachial artery flow-mediated dilatation (FMD) measured by ultrasonography, and lipid profile and insulin resistance evaluated by biochemical assays were compared between 34 women with a history of severe preeclampsia and 42 women with a prior normal pregnancy at least 1224 months postpartum. Results. CIMT was higher and FMD lower in the preeclamptic than in the control group. We found a significant inverse correlation between CIMT and FMD in the preeclamptic group, but no difference in lipid profiles and insulin resistance between the groups. Conclusions. Women with a history of severe preeclampsia exhibit early structural and functional preatherosclerotic vascular impairment, which might explain their higher risk of future cardiovascular disease. (c) Wiley Periodicals, Inc. J Clin Ultrasound 41:145-150, 2013; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI: 10.1002/jcu.21962