INVESTIGATION OF THE ROLE OF ICAM-1 E469K AND E-SELECTIN S128R POLYMORPHISMS IN DIABETIC NEUROPATHY


Oguz E. , Tabur S., Akbas H., Korkmaz H., Torun A., Dilmec F., ...Daha Fazla

ACTA MEDICA MEDITERRANEA, cilt.31, ss.1113-1118, 2015 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 31 Konu: 5
  • Basım Tarihi: 2015
  • Dergi Adı: ACTA MEDICA MEDITERRANEA
  • Sayfa Sayıları: ss.1113-1118

Özet

Introduction: Diabetic peripheral neuropathy is one of the commonest complications of diabetes. The soluble adhesion molecules, E-selectin and intracellular adhesion molecule (ICAM)-are indicators for endothelial activation. Recent studies demonstrated that these molecules are increased in patients with diabetes and diabetes-related complications. The present study was designed to investigate the possible association of two mutations, S128R in E-selectin and K469E in ICAM-1 with diabetic peripheral neuropathy (DPN) in Turkish population.