Protective effect of curcumin in cisplatin-induced oxidative injury in rat testis: mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways


ILBEY Y. O. , OZBEK E., Cekmen M. B. , SIMSEK A., OTUNCTEMUR A., SOMAY A.

HUMAN REPRODUCTION, cilt.24, ss.1717-1725, 2009 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 24 Konu: 7
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1093/humrep/dep058
  • Dergi Adı: HUMAN REPRODUCTION
  • Sayfa Sayısı: ss.1717-1725

Özet

The aim of this study was to investigate the cellular/biochemical mechanisms by which cisplatin (CIS) causes testicular toxicity. We evaluated the role of inducible nitric oxide synthase (iNOS) expression, mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-kB) activation in the pathogenesis of testicular damage induced by CIS, and investigated the effects of curcumin (CMN) against CIS-induced testicular injury in rats.