Efficacy of iloprost and montelukast combination on spinal cord ischemia/reperfusion injury in a rat model


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LAFCI G., GEDIK H. S. , KORKMAZ K., Erdem H., CICEK O. F. , NACAR O. A. , ...More

JOURNAL OF CARDIOTHORACIC SURGERY, vol.8, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 8
  • Publication Date: 2013
  • Doi Number: 10.1186/1749-8090-8-64
  • Title of Journal : JOURNAL OF CARDIOTHORACIC SURGERY

Abstract

Background: The thoracic or thoracoabdominal aortic aneurysm surgery may cause spinal cord ischemia because of aortic cross-clamping and may result in severe postoperative complications caused by spinal cord injury. Ischemia/reperfusion injury may directly or indirectly be responsible for these complications. In this study we sought to determine whether combination of iloprost and montelukast can reduce the ischemia/reperfusion injury of spinal cord in a rat model.