Efficacy of iloprost and montelukast combination on spinal cord ischemia/reperfusion injury in a rat model


LAFCI G., GEDIK H. S. , KORKMAZ K., Erdem H., CICEK O. F. , NACAR O. A. , et al.

JOURNAL OF CARDIOTHORACIC SURGERY, cilt.8, 2013 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 8
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1186/1749-8090-8-64
  • Dergi Adı: JOURNAL OF CARDIOTHORACIC SURGERY

Özet

Background: The thoracic or thoracoabdominal aortic aneurysm surgery may cause spinal cord ischemia because of aortic cross-clamping and may result in severe postoperative complications caused by spinal cord injury. Ischemia/reperfusion injury may directly or indirectly be responsible for these complications. In this study we sought to determine whether combination of iloprost and montelukast can reduce the ischemia/reperfusion injury of spinal cord in a rat model.