Food protein induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy that develops in infancy, equally common in both genders and regresses spontaneously until four years of age. Symptoms may begin with vomiting and diarrhoea following food intake and progress to hypovolemic shock. The usually accused food is cow's milk/soy protein. Disease has been reported to be triggered with potato/rice, chicken/fish and oat known as hypoallergic foods. It has recently been considered cell-mediated food allergy. Two cases of typical FPIES were presented to discuss our diagnostic and management approcahes, and to raise awareness among physicians.