Pretreatment with Dexmedetomidine or Thiopental Decreases Myoclonus after Etomidate: A Randomized, Double-Blind Controlled Trial


Mizrak A., Koruk S., Bilgi M., Kocamer B., Erkutlu I., Ganidagli S., ...More

JOURNAL OF SURGICAL RESEARCH, vol.159, no.1, 2010 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 159 Issue: 1
  • Publication Date: 2010
  • Doi Number: 10.1016/j.jss.2009.07.031
  • Journal Name: JOURNAL OF SURGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Keywords: etomidate, myoclonus, dexmedetomidine, thiopental, hyperalgesia, REDUCES MYOCLONUS, ANESTHETIC INDUCTION, PREFRONTAL CORTEX, GATED CURRENTS, INVOLVEMENT, MOVEMENTS, MIDAZOLAM

Abstract

Background. Myoclonic movements are common problems during induction of anesthesia with etomidate. The aim of this study was to compare the effect of pretreatment with dexmedetomidine (0.5 mu g/kg) and thiopental (1 mg/kg) on the incidence of etomidate-induced myoclonus and postoperative pain.