The Relationship Between Branched-Chain Amino Acids and Insulin Resistance


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Özkan G. Ö.

Current Research in Diabetes and Obesity Journal , cilt.12, ss.1-5, 2019 (Diğer Kurumların Hakemli Dergileri)

  • Cilt numarası: 12 Konu: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.19080/crdoj.2019.12.555830
  • Dergi Adı: Current Research in Diabetes and Obesity Journal
  • Sayfa Sayıları: ss.1-5

Özet

Obesity is a health problem worldwide and plays a role in the development of insulin resistance. In obese people, there occurs an increase in the level of branched-chain amino acids. Leucine, isoleucine and valine, which are among branched-chain amino acids, are essential amino acids. Branched-chain amino acids may create positive effects on body weight, muscle protein synthesis, and glucose homeostasis regulation. Despite the positive effects of branched-chain amino acids on metabolic health, an increase in their level in the body is associated with the increase in insulin resistance and type 2 diabetes risk. The degradation of branched- chain amino acid catabolism in the adipose tissue in obese individuals may contribute to an increase in the level of branched-chain amino acids in the case of obesity and insulin resistance. Branched-chain amino acids activate mammalian target of rapamycin complex 1 (mTORC1) and thus contribute to the development of insulin resistance. Furthermore, the degradation of branched- chain amino acid catabolism in obese individuals leads to an increase in the amount of toxic metabolites and causes beta cell dysfunction, which results in insulin resistance and glucose intolerance. Branched-chain amino acids, which are among the essential acids, might play a role in the development of insulin resistance. Putting a limitation on branched-chain amino acids in the diets of obese individuals can be considered as one of the precautions to be taken against the development of insulin resistance.