Effects of pentoxifylline on oxidative stress in rats with abdominal compartment syndrome model


Egin S., Açıksarı K. , Ercan G., Aydin A. F. , Ustyol E. A. , Eser M., ...More

INTERNATIONAL JOURNAL OF SURGERY OPEN, vol.5, pp.5-10, 2016 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 5
  • Publication Date: 2016
  • Doi Number: 10.1016/j.ijso.2016.09.001
  • Title of Journal : INTERNATIONAL JOURNAL OF SURGERY OPEN
  • Page Numbers: pp.5-10

Abstract

Background: Abdominal compartment syndrome (ACS) causes severe pathology in the cardiovascular, renal and pulmonary systems. Recent studies showed that pentoxifylline (PTX) has effects on increasing tissue oxygenation, healing capillary refill and reducing superoxides and hydroxyl radicals by inhibiting xanthine oxidase. In this study, our aim was to study the effects of PTX on free oxygen radicals and oxidative damage in rats with ACS model.