A Randomized Study of Allopurinol on Endothelial Function and Estimated Glomular Filtration Rate in Asymptomatic Hyperuricemic Subjects with Normal Renal Function


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KANBAY M. , Huddam B., Azak A., Solak Y., Kadıoğlu G., Kırbaş İ., ...More

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol.6, no.8, pp.1887-1894, 2011 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 8
  • Publication Date: 2011
  • Doi Number: 10.2215/cjn.11451210
  • Title of Journal : CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
  • Page Numbers: pp.1887-1894

Abstract

Background and objectives Endothelial dysfunction is an early manifestation of vascular injury and contributes to the development of atherosclerotic cardiovascular disease. Recent studies have implicated hyperuricemia as a risk factor for cardiovascular disease. We hypothesized that lowering uric acid in subjects with asymptomatic hyperuricemia with allopurinol might improve endothelial dysfunction, BP, estimated GFR (eGFR), and inflammatory markers.