A Randomized Study of Allopurinol on Endothelial Function and Estimated Glomular Filtration Rate in Asymptomatic Hyperuricemic Subjects with Normal Renal Function


KANBAY M. , Huddam B., Azak A., Solak Y., Kadıoğlu G., Kırbaş İ., et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, cilt.6, ss.1887-1894, 2011 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 6 Konu: 8
  • Basım Tarihi: 2011
  • Doi Numarası: 10.2215/cjn.11451210
  • Dergi Adı: CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
  • Sayfa Sayısı: ss.1887-1894

Özet

Background and objectives Endothelial dysfunction is an early manifestation of vascular injury and contributes to the development of atherosclerotic cardiovascular disease. Recent studies have implicated hyperuricemia as a risk factor for cardiovascular disease. We hypothesized that lowering uric acid in subjects with asymptomatic hyperuricemia with allopurinol might improve endothelial dysfunction, BP, estimated GFR (eGFR), and inflammatory markers.