Objective: Majority of nosocomial infections are seen in intensive care units (ICUs) and they course
with higher rates of mortality, and morbidity rates. In this study, we aimed to investigate the distri- bution of microorganisms isolated from the tracheal aspirate and blood cultures of ICU hospitalized
patients, and their antibiotic resistance profiles.
Method: Tracheal aspirate and blood cultures sent from ICU patients were evaluated retrospectively
between 2014-2018. Antimicrobial susceptibility tests were performed on microorganism cultures
that were identified by conventional methods and using an automated system.
Results: A total of 23.275 samples were accepted during the study period. The microorganisms isola- ted from tracheal aspirate cultures were Gram-negative (89.7%), Gram-positive (9.3%) and yeasts (1%).
The most common Gram (-) microorganisms were A.baumannii (%25.7). The rates of meropenem re- sistance were documented as 98.3% for A.baumannii in 2014, 95.7% in 2018, 69.2% for P.aeruginosa.
in 2014, and 35.6% in 2018, 45.55 for K.pneumoniae in 2014, and 5.8% in 2018 and 8% for E.coli
in 2014, and 2% in 2018. The rates of methicillin resistance in S.aureus were documented as 28.0%
in 2018, and 67.7% in 2015. The rates of penicillin resistance for S. pneumonia was documented as
76.8% in 2018, and 13.4% in 2015. The microorganisms isolated from blood culture were Gram (-)
(31.4%), Gram (+) (57.9%) and yeasts (10.6%). The most frequently isolated Gram (-) bacteria were
K.pneumonia (9.3%) and A.baumannii (8.8%). The rates of meropenem resistance were documented
as 97.3% for A.baumannii. in 2014 and 79.2% in 2018, as 76.9% for K.pneumoniae in 2014 and 37.3%
in 2018 and 79.2% for P.aeruginosa in 2014 and 26.1% in 2018. The artes of methicillin resistance were
documented as 89.2% in 2018, and 78.5% for CNS in 2015, and 42.6% in 2018 while it was 92.4%
for S. aureus in 2015
Conclusions: Our study showcased a drop throughout the year in rates of carbapenem resistance
against Gram (-) microorganisms and methicillin resistance in S.aureus. However, the persistently high
carbapanem resistance in A.baumannii isolates demonstrates the crucial need to continue with infec- tion control measures.