Effect of pinealectomy and. melatonin replacement on morphological and biochemical recovery after traumatic brain injury


Ateş O., Çaylı S., Gürses I., Yücel N., Iraz M., Altınöz E., ...More

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, vol.24, no.6, pp.357-363, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 6
  • Publication Date: 2006
  • Doi Number: 10.1016/j.ijdevneu.2006.08.003
  • Title of Journal : INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
  • Page Numbers: pp.357-363

Abstract

Numerous studies showed that melatonin, a free radical scavenger, is neuroprotective. In this study, we investigated the effect of pinealectomy and administration of exogenous melatonin on oxidative stress and morphological changes after experimental brain injury. 

The animals were divided into six groups, each having 12 rats. Group I underwent craniotomy alone. Group 2 underwent craniotomy followed by brain trauma and received no medication. Group 3 underwent craniotomy followed by brain trauma and received melatonin. Group 4 underwent pinealectomy and craniotomy alone. Group 5 underwent pinealectomy and craniotomy followed by brain injury and received no medication. Group 6 underwent pinealectomy and craniotomy followed by brain trauma and received melatonin. Melatonin (100 mg/kg) was given intraperitoneally immediately after trauma to the rats in Groups 3 and 6. 

Numerous studies showed that melatonin, a free radical scavenger, is neuroprotective. In this study, we investigated the effect of pinealectomy and administration of exogenous melatonin on oxidative stress and morphological changes after experimental brain injury.