Effect of pinealectomy and. melatonin replacement on morphological and biochemical recovery after traumatic brain injury

Ateş O., Çaylı S., Gürses I., Yücel N., Iraz M., Altınöz E., et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, cilt.24, ss.357-363, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 24 Konu: 6
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.ijdevneu.2006.08.003
  • Dergi Adı: INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
  • Sayfa Sayısı: ss.357-363

Özet

Numerous studies showed that melatonin, a free radical scavenger, is neuroprotective. In this study, we investigated the effect of pinealectomy and administration of exogenous melatonin on oxidative stress and morphological changes after experimental brain injury.

Numerous studies showed that melatonin, a free radical scavenger, is neuroprotective. In this study, we investigated the effect of pinealectomy and administration of exogenous melatonin on oxidative stress and morphological changes after experimental brain injury. 

The animals were divided into six groups, each having 12 rats. Group I underwent craniotomy alone. Group 2 underwent craniotomy followed by brain trauma and received no medication. Group 3 underwent craniotomy followed by brain trauma and received melatonin. Group 4 underwent pinealectomy and craniotomy alone. Group 5 underwent pinealectomy and craniotomy followed by brain injury and received no medication. Group 6 underwent pinealectomy and craniotomy followed by brain trauma and received melatonin. Melatonin (100 mg/kg) was given intraperitoneally immediately after trauma to the rats in Groups 3 and 6.