The neuroprotective effect of lamotrigine against glutamate excitotoxicity in SH-SY5Y human neuroblastoma cells


TERZİOĞLU BEBİTOĞLU B., OĞUZ E., Acet N. G. , Hodzic A., Temel F., ADA S. , ...Daha Fazla

MARMARA MEDICAL JOURNAL, cilt.33, sa.3, ss.146-152, 2020 (ESCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Konu: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.5472/marumj.816319
  • Dergi Adı: MARMARA MEDICAL JOURNAL
  • Sayfa Sayıları: ss.146-152

Özet

Objective: Glutamate-induced excitotoxicity has a role in the pathophysiology of neurodegenerative disorders. Lamotrigine, an antiepileptic drug, also used to treat bipolar disorders, may be protective against excitotoxic insult. The aim of the study was to investigate the neuroprotective effect of lamotrigine against the glutamate excitotoxicity in SH-SY5Y cell line.