Anti-Toxoplasma gondii antibodies in patients with schizophrenia-preliminary findings in a Turkish sample


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ÇETİNKAYA Z., YAZAR S., GEÇİCİ Ö., NAMLI M.

SCHIZOPHRENIA BULLETIN, vol.33, no.3, pp.789-791, 2007 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 3
  • Publication Date: 2007
  • Doi Number: 10.1093/schbul/sbm021
  • Title of Journal : SCHIZOPHRENIA BULLETIN
  • Page Numbers: pp.789-791

Abstract

Schizophrenia is a serious neuropsychiatric disease of uncertain etiology. We investigated the seropositivity rate for anti-Toxoplasma IgG and IgNI antibodies by enzymelinked immunosorbent assay (ELISA) in patients with schizophrenia to ascertain a possible relationship between Toxoplasma gondii and schizophrenia. We selected 100 patients with schizophrenia, 50 with depressive disorder, and 50 healthy volunteers to investigate the seropositivity rate of anti-Toxoplasma antibodies by ELISA. The seropositivity rate for anti-Toxoplasma IgG antibodies among schizophrenia patients (66%) was significantly higher than among patients with depressive disorder or healthy volunteers (P <.01). Thus, there might be a causal relationship between toxoplasmosis and the etiology of schizophrenia.