Community-acquired CTX-M-15-type ESBL-producing Escherichia coli meningitis: a case report and literature review


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Elaldi N., Gozel M. G. , KOLAYLI F., Engin A., Celik C., Bakici M. Z. , et al.

JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, cilt.7, ss.424-431, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 7 Konu: 5
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3855/jidc.2820
  • Dergi Adı: JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
  • Sayfa Sayısı: ss.424-431

Özet

In this report, a case of community-acquired acute bacterial meningitis (CA-ABM) caused by CTX-M-15-producing Escherichia coli in an elderly male patient was presented in the light of literature. Cultures of cerebrospinal fluid, blood, ear discharge, and stool samples yielded CTX-M-15-producing E. coli in-vitro, which was resistant to the extended-spectrum cephalosporins and ciprofloxacin and susceptible to imipenem, meropenem and amikacin. Meningitis was treated with parenteral meropenem plus parenteral and intraventricular amikacin administration. Since bacterial meningitis is a life-threatening infection, empiric antibiotic therapy with carbapenem can be started before the culture results are obtained, mainly in areas where the ESBL epidemiology is well known.