Effects of lycopene in intestinal ischemia reperfusion injury via intestinal immunoglobulin A

Ikiz O., KAHRAMANSOY N., Erkol H., Kocoglu E., FIRAT T.

JOURNAL OF SURGICAL RESEARCH, vol.267, pp.63-70, 2021 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 267
  • Publication Date: 2021
  • Doi Number: 10.1016/j.jss.2021.04.039
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.63-70
  • Keywords: Lycopene, Mesenteric ischemia, Intestinal ischemia reperfusion, Immunoglobulin A, Bacterial translocation, Intestinal barrier, SPINAL-CORD-INJURY, RETINOIC ACID, RATS, INNATE, DAMAGE, DYSFUNCTION, BARRIER


Background: Intestinal ischemia causes an inflammatory response that may become intense by reperfusion and result in bacterial translocation. Intestinal immunoglobulin A is known to be a barrier against bacterial translocation. Lycopene is a compound with antioxidant and anti-inflammatory properties. We hypothesized that lycopene has positive effects in ischemia-reperfusion of the intestine through the intestinal IgA.