Synthesis and antimicrobial activity of new thiazole-2(3H)-thiones containing 1,1,3-trisubstituted cyclobutane


AHMEDZADE M., KIRILMIS C., CUKUROVALI A., Dilsiz N.

SOUTH AFRICAN JOURNAL OF CHEMISTRY-SUID-AFRIKAANSE TYDSKRIF VIR CHEMIE, vol.56, pp.21-24, 2003 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 56
  • Publication Date: 2003
  • Title of Journal : SOUTH AFRICAN JOURNAL OF CHEMISTRY-SUID-AFRIKAANSE TYDSKRIF VIR CHEMIE
  • Page Numbers: pp.21-24

Abstract

The reaction of potassium salts of RNHCSSK with 2-chloro-1-(3-methyl-3-phenylcyclobutyl)ethan-1-one in ethanol at 78-80degreesC afforded new 1,3-thiazole-2(3H)-thiones containing 1,1,3-trisubstituted cyclobutane rings at C-4. The antimicrobial activities of these compounds were also investigated against seven different microorganisms, and some of them were found to be active against several of the microorganisms at higher concentrations.