SIRT1 as a potential therapeutic target for treatment of nonalcoholic fatty liver disease

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Çolak Y., Öztürk O., Şenateş E., TUNCER İ., Yorulmaz E., Adalı G., ...More

MEDICAL SCIENCE MONITOR, vol.17, no.5, 2011 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 5
  • Publication Date: 2011
  • Doi Number: 10.12659/msm.881749
  • Journal Indexes: Science Citation Index Expanded, Scopus


Sirtuins are members of the silent information regulator 2 (Sir2) family, a group of Class III histone/protein deacetylases. There are 7 different sirtuins in mammals (SIRT1-7), of which SIRT1 is the best known and most studied. SIRT1 is responsible for the regulation of protein activation by means of deacetylating a variety of proteins that play important roles in the pathophysiology of metabolic diseases. Recently, it has been shown that SIRT1 plays key roles in the regulation of lipid and glucose homeostasis, control of insulin secretion and sensitivity, antiinflammatory effects, control of oxidative stress and the improvements in endothelial function that result due to increased mitochondrial biogenesis and beta-oxidation capacity.