The Effects of Vitamin C Administration, Acute Food Deprivation, and Acute Food Intake on Vitamin C Levels in Different Brain Areas of Guinea Pigs


Kaplan B., Cetin F. , Elbeg S.

INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH, cilt.80, ss.197-204, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 80 Konu: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1024/0300-9831/a000016
  • Dergi Adı: INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
  • Sayfa Sayısı: ss.197-204

Özet

Vitamin C is crucial for the brain. We aimed to investigate the effects of vitamin C administration following 24 hours of acute food deprivation and 24 hours of acute food intake on changes ill vitamin C levels in different brain areas of guinea pigs. Vitamin C was administered as a single intraperitoneal dose (500 mg kg(-1) body weight) both before acute food deprivation and before acute food intake. At the end of our study, we measured the vitamin C levels in cerebral cortex lobes, brain stem structures, hypophysis, hypothalamus, cerebellum, hippocampus, and amygdala. Vitamin C levels in the frontal and parietal lobes were found to be significantly higher in animals pretreated with vitamin C prior to 24 hours of food deprivation (p < 0.05). Temporal lobe vitamin C level was significantly lower in animals that were subjected to 24 hours of acute food intake following 24 hours of food deprivation (p < 0.05). Increased vitamin C levels were observed in the occipital lobe of all animals that received vitamin C administration (p < 0.05). Vitamin C levels in the brain stem structures such as mesencephalon and pons were significantly decreased in animals pretreated with vitamin C before normal feeding (p < 0.05). Vitamin C level in the hypothalamus was significantly increased after 24 hours of food deprivation (p < 0.05). In conclusion, different areas of the brain may differ in terms of vitamin C content during nutritional changes with or without vitamin C pretreatment, such as 24 hours of food deprivation or 24 hours of food intake following 24 hours of food deprivation. These differences may be attributed to several functions of vitamin C which may occur under these circumstances.