Immunohistochemical analysis of connective tissue in patients with pelvic organ prolapse


Yucel N., Usta A., Guzin K., Kanter M., Bilgic E., Ozel N. O. , ...More

JOURNAL OF MOLECULAR HISTOLOGY, vol.44, no.1, pp.97-102, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.1007/s10735-012-9456-5
  • Title of Journal : JOURNAL OF MOLECULAR HISTOLOGY
  • Page Numbers: pp.97-102

Abstract

The uterosacral ligaments are an important part of the pelvic support system. The objective of this study was to compare the expression of collagen type I and collagen type III in the uterosacral ligament biopsies from women with and without pelvic organ prolapse (POP). The uterosacral ligament biopsies were obtained from women with POP (n = 29) and non-POP subjects (n = 35). Immunohistochemistry for collagen type I and collagen type III was performed on formalin-fixed and paraffin-embedded sections. The two groups were matched for age, body mass index, parity and postmenopausal status. The expression of collagen type I (p < 0.001) and collagen type III (p < 0.0001) differed between women with POP and non-POP subjects. There was decreased expression of collagen type I and increased expression of collagen type III in uterosacral ligaments of women with POP compared with non-POP subjects. This difference indicates a possible relationship between POP and the immunohistochemical expression of collagen type I and collagen type III in uterosacral ligaments.