Effects of resveratrol in inflammatory arthritis


ELMALI N., BAYSAL Ö., HARMA A., ESENKAYA İ. , MIZRAK B.

INFLAMMATION, cilt.30, ss.1-6, 2007 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 30
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1007/s10753-006-9012-0
  • Dergi Adı: INFLAMMATION
  • Sayfa Sayısı: ss.1-6

Özet

Nuclear factor kappa B (NF-kappa B), is a pivotal transcription factor involved in the activation of the TNF-alpha and IL-1 beta genes. Activation of NF-kappa B in synovial cells is a feature seen in arthritis patients. Resveratrol, a polyphenolic, natural phytoalexin found with particularly high levels in grape skin and red wine is potent and specific inhibitor of TNF-alpha and IL-1 beta induced NF-kappa B activation. We aimed to determine the in vivo effects of intra-articular injections of resveratrol on cartilage and synovium in an experimental rabbit inflammatory arthritis model.