Monitoring of hepatitis B virus surface antigen escape mutations and concomitantly nucleos(t)ide analog resistance mutations in Turkish patients with chronic hepatitis B


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SAYAN M., Senturk O., AKHAN S., HÜLAGÜ S., Cekmen M. B.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, vol.14, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14
  • Publication Date: 2010
  • Doi Number: 10.1016/j.ijid.2009.11.039
  • Title of Journal : INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Abstract

Background: The hepatitis B virus (HBV) polymerase gene completely overlaps with the envelope gene. In the present study we aimed to monitor the prevalence and pattern of the typical mutations for hepatitis B surface antigen (HBsAg) escape, and concomitantly nucleos(t)ide analog (NUC) resistance mutations, in Turkish patients undergoing different antiviral therapies and in treatment-naive patients with chronic hepatitis B (CHB).