Monitoring of hepatitis B virus surface antigen escape mutations and concomitantly nucleos(t)ide analog resistance mutations in Turkish patients with chronic hepatitis B


SAYAN M., Senturk O., AKHAN S., HÜLAGÜ S., Cekmen M. B.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, cilt.14, 2010 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 14
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.ijid.2009.11.039
  • Dergi Adı: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Özet

Background: The hepatitis B virus (HBV) polymerase gene completely overlaps with the envelope gene. In the present study we aimed to monitor the prevalence and pattern of the typical mutations for hepatitis B surface antigen (HBsAg) escape, and concomitantly nucleos(t)ide analog (NUC) resistance mutations, in Turkish patients undergoing different antiviral therapies and in treatment-naive patients with chronic hepatitis B (CHB).