Acanthosis nigricans and the metabolic syndrome

KARADAĞ A. S. , You Y., Danarti R., Al-Khuzaei S., Chen W.

CLINICS IN DERMATOLOGY, vol.36, no.1, pp.48-53, 2018 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.1016/j.clindermato1.2017.09.008
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.48-53


Acanthosis nigricans (AN) describes clinically a darkly pigmented thickening skin, which produces epidermal and dermal hyperplasia with orthokeratotic hyperkeratosis and papillomatosis of the stratum spinosum with basal layer hyperpigmentation, in the absence of actual acanthosis and melanocytosis on histologic examination. It is a reactive cutaneous change closely associated with obesity, insulin resistance, and hyperinsulinemia; endocrinopathy; or malignancy, in particular gastrointestinal adenocarcinoma. The prevalence varies, and ethnicity seems an independent factor. Evidence indicates that AN is a useful clinical marker to identify patients susceptible to insulin resistance, the MetS, and type 2 diabetes.