Serum Concentrations of Galectin-3 in PatientswithCoronaryArteryEctasia


Atıcı A.

13th International Congress of Update in Cardiology and Cardiovascular Surgery, İzmir, Türkiye, 23 - 26 Mart 2017, no.207, ss.26

  • Basıldığı Şehir: İzmir
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayısı: ss.26

Özet

Objective: Galectin-3 (Gal-3) is a multifunctional matricellular protein associated with heart failure and cardiovascular events. Galectin-3 represents a valuable biomarker for both progression and destabilization of atherosclerotic lesions. An important characteristic of coronary artery ectasia (CAE) is the fact that in 85% of the cases, atherosclerotic coronary disease accompanies it. The relation between CAE and serum galectin -3 has not been studied so far. We compared A1AT serum levels in patients with and without CAE to determine the association between serum Galectin -3 levels and the extent of ectasia using the Markis score. Methods: We included 49 patients (38 males) with isolated CAE patients and 43 controls (12 males) with normal coronary arteries after coronary angiography. Serum concentrations of galectin-3 were measured on the blood samples. Results: The median Galectin-3 levels were significantly higher in patients with isolated CAE than in the control group (23.2 ng/mL [range: 16.08 e 30.0 ng/mL]; vs (16.8 ng/mL [range: 25.0-10.5ng/mL] P <.001). According to the Markis classification, the extent of CAE was not correlated with Galectin -3 levels (P¼0.41). Although, the prevalence of family history of coronary artery disease (CAD), uric acid were higher among patients with CAE, In addition, concentrations of galectin-3 and uric acid were determined as independent predictors of the CAE. Conclusions: It was found that galectin-3 serum concentrations are higher in patients with CAE than that in control participants with normal coronary arteries, Further studies on larger population are needed to confirm the potential role of galectin-3 in the CAE suggesting that Galectin-3 may be involved in the pathogenesis of CAE. Keywords: Coronary Artery Ectasia (CAE), Galectin-3 (Gal-3), x