Objective: Sarcomatoid urothelial carci- noma has an aggressive nature; a worse prog- nosis, a more advanced stage and a greater risk of metastasis than other types of urot- helial cancers. In this study, the clinical and histopathological results of 10 patients with sarcomatoid urothelial carcinoma of the blad- der will be presented and the current literature will be reviewed.
Material and Methods: The study inclu- ded 10 patients histopathologically diagnosed as sarcomatoid carcinoma between November 2012 and December 2018. Demographic cha- racteristics and pathology results were evalu- ated retrospectively. Patients were evaluated with detailed history, physical examination, routine biochemical and hematological exa- mination, urinary ultrasonography, abdomi- nopelvic tomography, chest radiography and cystoscopy before surgery.
Results: The mean age and mean follow- up period of the patients were 70.2 (51-81) years and 9.2 (2-18) months respectively. The mean symptom of the patients was macrosco- pic hematuria. Six (60%) patients underwent radical cystectomy. One patient received neo- adjuvant chemotherapy. One (16.6%) patient had a stage of pT2b tumor, three (50%) pati- ents had a stage of pT3 tumor and two (33.3%) patients had a stage of pT4 tumor after radicalcystectomy. Three (50%) patients were found to have N1 disease and three (50%) patients had coexisting carcinoma in situ (CIS). Metastasis for lymph node involvement was present in three (50%) of the patients. Six (60%) patients have died due to disease, four (40%) patients are still continued to follow up.
Conclusion: Sarcomatoid carcinoma of the bladder is usually an aggressive tumor and patients are referred with advanced stages. Despite radical surgery, these patients should be followed up closely as early recurrence and progression can be seen.