INCREASED CHITOTRIOSIDASE ACTIVITIES IN PATIENTS WITH RHEUMATOID ARTHRITIS: A POSSIBLE NOVEL MARKER?


BASOK B. I. , Kucur M., KIZILGUL M., YILMAZ I., Ekmekci O. B. , Uzunlulu M. , ...More

JOURNAL OF MEDICAL BIOCHEMISTRY, vol.33, no.3, pp.245-251, 2014 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 3
  • Publication Date: 2014
  • Doi Number: 10.2478/jomb-2014-0010
  • Title of Journal : JOURNAL OF MEDICAL BIOCHEMISTRY
  • Page Numbers: pp.245-251

Abstract

Background: Chitotriosidase and YKL-40 are well-known in humans as Glyco_18 domain-containing proteins that are the common feature of mammalian chitinases and chitinase-like proteins. Previously, increased levels of YKL-40 were found correlated with the disease activity of rheumatoid arthritis. However, serum chitotriosidase activity in rheumatoid arthritis is not known yet. The aim of this study was to determine YKL-40 and chitotriosidase in patients with rheumatoid arthritis and to compare these markers with traditional ones such as C-reactive protein and erythrocyte sedimentation rate.