The purpose of the present study was to investigate the anti-apoptotic bcl-2 protein in rat brain and testes after whole-body exposure to radiation emitted from 900 MHz cellular phones. Two groups (sham and experimental) of Sprague-Dawley rats of eight rats each were used in the study. Exposure began approximately 10 min after transferring into the exposure cages, a period of time when rats settled down to a prone position and selected a fixed location inside the cage spontaneously. For the experimental group, the phones were in the speech condition for 20 min per day for I month. The same procedure was applied to the sham group rats, but the phones were turned off Immunohistochemical staining of bcl-2 was performed according to the standardized avidin-biotin complex method. The results of this study showed that 20 mn of the radiation emitted from 900 MHz cellular phones did not alter antiapoptotic bcl-2 protein in the brain and testes of rats. We speculate that bcl-2 may affects of radiation on the brain and testes of rats. not be involved in the effects of radiation on the brain and testes of rats.