Does isotretinoin therapy have any effects on electrocardiography, heart rate and blood pressure?

KARADAĞ A. S. , Gümrükçüoğlu H., Bilgili S., Uce Özkol H., Ertugrul D., Simsek H., ...More

JOURNAL OF DERMATOLOGICAL TREATMENT, vol.23, no.3, pp.168-171, 2012 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.3109/09546634.2010.546831
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.168-171


Background: Isotretinoin therapy is associated with numerous adverse effects of various systems. Although some cases have been reported, cardiac side effects are rare following isotretinoin treatment. Objective: To investigate the effects of isotretinoin on the cardiovascular system. Methods: Seventy patients with acne vulgaris were enrolled in the study. The patients were treated with a dose of 0.5-1.0 mg/kg per day of isotretinoin. Screening for biochemical and hematologic parameters, heart rate, blood pressure and electrocardiographic parameters were done before treatment and after 3 months of isotretinoin treatment. Results: Heart rate, systolic/diastolic tension and electrocardiographic parameters (P-wave duration and QTc duration) were not statistically different before compared with after treatment. Conclusion: As far as we know, there is no study researching the effect of isotretinoin on P- and QT-wave measurements in the literature. We found that isotretinoin did not affect P- and QT-wave measurement. Further studies with longer periods of follow-up are needed to understand the effect of isotretinoin on the cardiovascular system.