Ursodeoxycholic acid treatment in preterm infants: A pilot study for the prevention of cholestasis associated with total parenteral nutrition


Arslanoglu S. , MORO G. E. , TAUSCHEL H., BOEHM G.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, cilt.46, ss.228-231, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 46 Konu: 2
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1097/mpg.0b013e3181560524
  • Dergi Adı: JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
  • Sayfa Sayıları: ss.228-231

Özet

In a prospective, double-blind, placebo-controlled trial, the efficacy and safety of ursodeoxycholic acid (UDCA) was evaluated in preterm infants, in terms of its potential impact on fat absorption, advancement of enteral feeding, development of cholestasis, growth, nutritional status, and metabolic status. Although fecal fat excretion slightly decreased and achievement of full enteral feeding was earlier in the UDCA group, these differences were not significant. Interestingly, whereas serum gamma-glutamyl transferase activity increased during the parenteral nutrition period in the placebo group, we observed a constant and significant decrease in the UDCA group. This observation warrants further investigation to determine the utility of prophylactic UDCA in preventing cholestasis in infants with prolonged parenteral nutrition.