In this study, the optimization of the digital holography setup is achieved by a using fuzzy logic prediction system. In fact, when this optimization process is experimentally performed, some parameters are changed in the setup. These parameters affect directly the obtained image quality after a reconstruction process, which is determined by normalized root mean square. The aim of this study is to achieve the optimization of digital holographic setup by using both experimental and fuzzy logic prediction systems. Furthermore, the required time during the experimental optimization can be lowered by using a numerical method like the fuzzy logic prediction system. Here, the experimental optimization results and the optimization results obtained by the fuzzy logic prediction system are compared. It is offered that the designed experimental system can be optimized by using an artificial intelligent tool. The applied fuzzy logic prediction model is used the first time for optimization of hologram recording setup. As a result, it is reached a conclusion that the optimization of digital holographic setup can be numerically performed by the fuzzy logic prediction system. Moreover, while digital holographic setup is experimentally designed, the required time for optimization is reduced, as well. (C) 2016 Elsevier Ltd. All rights reserved.