JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, cilt.29, ss.135-139, 2016 (SCI İndekslerine Giren Dergi)
Objectives: To compare the efficacy of oral and intravenous paracetamol for closure of hemodynamically significant patent ductus arteriosus (HSPDA) in very low birth weight (VLBW) preterm infants.Methods: Eighteen VLBW infants with HSPDA treated with either intravenous (n=10) or oral (n=8) paracetamol at 60mg/kg/d for three consecutive days were analysed retrospectively. Ductal closure rate and evaluation of liver function tests were the major outcomes.Results: After two courses of treatment, HSPDA closure rate was higher in oral paracetamol group than that in the intravenous paracetamol group (88% versus 70%), but it was not statistically significant (p=0.588). Liver function tests were normal after the treatment.Conclusion: Although it was not statistically significant, the cumulative closure rates were higher in oral paracetamol group than those in the intravenous group. Larger trials are needed to confirm these data.