Evaluation of common mutations in the Mediterranean fever gene in Multiple Sclerosis patients: Is it a susceptibility gene?


Unal A., Dursun A., Emre U., Tascilar N. F. , Ankarali H.

JOURNAL OF THE NEUROLOGICAL SCIENCES, cilt.294, ss.38-42, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 294
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.jns.2010.04.008
  • Dergi Adı: JOURNAL OF THE NEUROLOGICAL SCIENCES
  • Sayfa Sayısı: ss.38-42

Özet

Purpose: Multiple Sclerosis (MS) is a disease of the central nervous system characterized by multiple areas of inflammation and demyelination in the white matter of the brain and spinal cord. MEFV gene, which is the main factor in familial Mediterranean fever, is an intracellular regulator of inflammation. This study was designed to determine if known mutations in pyrin domain of MEFV gene are involved in MS and associated with MS morbidity.