Mean platelet volume (MPV) has been recognized as an independent risk factor of hypertension. Hypertensive end-organ damage worsens the prognosis in hypertensive patients. We aimed to investigate the relationship between MPV levels and subclinical end-organ damage in hypertensive patients. One hundred and sixteen hypertensive patients (81 women, 35 men, with a mean age of 53 +/- 11) were included in the study. There was no correlation between MPV and left-ventricular mass index (LVMI) (r=0.145; P=0.14) or albuminuria (r=0.009; P=0.93). Among the individuals that had grade I and grade II retinopathy, MPV levels (8.3 +/- 2 fL, 8.2 +/- 1.3 fL; P=0.28) were similar either. We concluded that there was no correlation between MPV and markers of end-organ damage in hypertensive patients. Blood Coagul Fibrinolysis 23:367-369 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.