Reduced PON1 enzymatic activity and increased lipid hydroperoxide levels that point out oxidative stress in generalized anxiety disorder

Bulut M., Selek S., Bez Y., Karababa I. F. , Kaya M. C. , Gunes M., et al.

JOURNAL OF AFFECTIVE DISORDERS, cilt.150, ss.829-833, 2013 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 150 Konu: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.jad.2013.03.011
  • Sayfa Sayısı: ss.829-833


In recent years, there has been an increasing focus on generalized anxiety disorder (GAD) which is one of the most prevalent mental disorders in general population. Psychological, genetic, neurobiological, and neurochemical factors are believed to play role in the etiopathogenesis of GAD. The role of oxidative stress, as a neurochemical cause, in various anxiety disorders has been studied in recent years; however, it has not been thoroughly studied in GAD, yet. In this paper, we aimed to evaluate the serum levels of lipid hydroperoxide (LOOH), paraoxonase, and arylesterase in GAD patients without any co-morbid psychiatric disorders and investigate their diagnostic performance.